Fig. 8.

DTP@KA NPs alleviated inflammation and multiple organ damage. A–C. Activity assay IL-1β (A), IL-6 (B) and MPO (C) in pancreas. D. Protein expressions of p-P65 and caspase3. E. Quantitative analysis of p-P65 and caspase3 protein expressions. F. Representative HE images of spleen and lung tissues. Scar bar = 100 μm. G. Spleen scores. H. Lung scores. Data represent the mean ± SEM of at least three independent experiments; n = 5–8/group. Significance: ^* p < 0.05 and ^**p < 0.01 vs. the control group; ^# p < 0.05 and ^## p < 0.01 vs. the SAP model group