Figure 3.

Forest plot of comparison: reactive case detection and treatment (RACDT) versus reactive drug administration (RDA) on prevalence of malaria infection. ¹The 95% CI upper limit presented here is artificially lower than in the published paper (odds ratio = 1.85, 95% CI: 0.96–20.00), because the authors of the Namibia trial calculated the effect size using marginal effects post-estimation (to account for reactive indoor residual spraying [IRS] in half the clusters) after a regression model, and Review Manager software can only accommodate balanced CIs. Effect size from (nonlinear) marginal effect post-estimation from generalized estimating equations (GEE) model using a logit function adjusted for reactive IRS, the interaction between reactive IRS and RDA, 2016 incidence of local cases, index case level and target population coverage for RDA or RACDT, response time, and co-interventions by Namibia Ministry of Health. Unadjusted effect size (from postestimation marginal effect of RDA from GEE model using a logit function adjusted for reactive IRS, the interaction between reactive IRS and RDA but no other covariates): 0.95 (95% CI: 0.48–33.3).