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Case 42, from the vulva of an 84-year-old woman. A, (Hematoxylin & Eosin, 2×). A nevoid melanoma, with multiple CMA aberrations. B, CMA output. There is a clear deletion at the CDKN2A locus; all the reference genes are unaffected. This CDKN2A loss was biallelic, per Chromosome Analysis Suite, Thermo Fisher Scientific analysis. The mean ddPCR output for this sample was 0.48, well below the ddPCR cutoff of 1.11 for biallelic CDKN2A loss.
