FIGURE 5.

Trends in the data. Error bars represent SD. The average CDKN2A ddPCR output for benign lesions was 2.06 (SD 0.18), followed by 1.90 (SD 0.26) for borderline lesions, 1.29 (SD 0.55) for primary melanomas, and 1.20 (SD 0.52) for metastatic melanomas. Significant differences (2-sample t test) are indicated by asterisks. Notably, the degree of copy number loss increased with increasing atypia. Although this study was not designed to delineate atypia from copy number alone, future work could explore this area further.