Fig. 3.

Cont. B) Pathology macroscopic visualization, margin measurement, and tumor location. C) Intra-operative design of implant procedure of a patient with a peri-areolar incision. Topographical identification of a high-risk area of tumor bed in surgical cavity (solid white line), with clip references (white arrows). The area to be implanted corresponds to a tumor bed plus a 1-2 cm margin, based on visualization of breast specimen and tumor location with margin relationship. D) Final breast conserving surgery with IOB. E) CT planning with CTV, clips, OARs delineation, catheter reconstruction, and isodose distribution