Figure 1.

General clinicopathological schema. The problem always starts with the patient. Clinical presentations are first linked to specific pathologies (in the case of neuropsychiatry, neuropathologies), from which hypotheses emerge and then get tested in laboratory models. From the latter emerge more refined hypotheses or diagnostic and therapeutic ideas that take the inquiry from the bench back to bedside. The cycle can be repeated many times to further understanding of the disease and improved diagnostics and therapeutics.