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. Author manuscript; available in PMC: 2025 Mar 14.
Published in final edited form as: J Med Chem. 2024 Feb 3;67(5):3668–3678. doi: 10.1021/acs.jmedchem.3c02128

Table 3.

Biological data for biphenyl galactosides and galactosaminosides 57−71.

graphic file with name nihms-1977077-t0016.jpg
Compound Name R1 R2 R3 R4 IC50 (μM)a cLogP cLogD7.4 CMR (cm3/mol) tPSA (Å2)
I 21 H NHSO2Me H H 0.035 1.9 0.7 11.92238 154.4
57 H F H F 6.0 3.1 2.3 10.28273 108.2
58 H F H CF3 9.0 4.1 2.9 10.85846 108.2
59 H F H CN 2.0 2.6 1.7 10.83486 132
60 H F H OMe 6.0 3 2.1 10.90741 117.5
61 H CF3 H CN 6.0 2.5 2.3 11.41059 132
62 H CF3 H OMe 18 4 2.7 11.48314 117.5
63 F F F H 0.70 3.2 2.4 10.30437 108.2
64 F F H H 0.59 3 2.2 10.28273 108.2
65 F H H H 0.71 2.8 1.9 10.26109 108.2
66 F H F H 0.32 3.1 2.1 10.28273 108.2
67 (AM4075) H F F H 0.24 2.7 2.3 10.28273 108.2
68 H F H H 0.48 2.8 2 10.26109 108.2
69 (AM4085) H H F H 0.19 2.9 2.1 10.26109 108.2
70 H NHSO2Me F H 0.89 2 0.6 11.94402 154.4
71 H NHSO2Ph F H 0.19 3.5 1.5 13.94431 154.4
a

All the IC50 values are an average of four replicates