Table 3.

Summary of the Comparison of Fractional Anisotropy (FA) Values in Major Depressive Disorder as Compared to Healthy Controls (HC) Participants

	UNC- L	UNC-R	UNC-B	CGC-L	CGC-R	CGC-B	CGH-L	CGH-R	CGH-B	ATR-L	ATR-R	ATR-B	ACR-L	ACR-R	ACR-B	IC-L	IC-R	ALIC-B	IFO-L	IFO-R	IFO-B
Lee et al. (2021)29		↑		↑	↑						↑			↑						↑
Wu et al. (2020)18	↓	-
van Velzen et al. (2020)22			-			-			-						-			-			-
Cullen et al. (2020)30	↑(u)	-		↑(u)	↑(u)		-	-		-	-
Geng et al. (2016)34
LeWinn et al. (2014)17	↓	↓		-	-									↓		↓	↓		↓	↓
Aghajani et al. (2014)35	↑
Henderson et al. (2013)21					↓ (u)		↑(u)
Bessette et al. (2014)19	↓			↓			↓				↓		↓	↓		↓	↓			↓
Cullen et al. (2010)20	↓(u)	↓(u)		↓(u)															↓(u)	↓(u)
Wu et al. (2022)36
Total Number	6	3		4	3		2				2		1	3		2	2		2	4

	SLF-L	SLF-R	SLF-B	ILF-L	ILF-R	ILF-B	CST-L	CST-R	CST-B	SCR-L	SCR-R	SCR-B	Fornix-B	GCC	BCC	SCC	EC-L	EC-R	PTR-L	PTR-R	PTR-B
Lee et al. (2021)29														↑	↑			↑
Wu et al. (2020)18
van Velzen et al. (2020)22			-						-			-	-		↓(u)						-
Cullen et al. (2020)30	-	-		-	-		-	-
Geng et al. (2016)34													↓
LeWinn et al. (2014)17										↓	↓			↓	↓		↓	↓
Aghajani et al. (2014)35															↓
Henderson et al. (2013)21
Bessette et al. (2014)19				↓						↓	↓			↓	↓		↓		↓
Cullen et al. (2010)20	↓(u)
Wu et al. (2022)36
Total Number	1			1						2	2		1	3	5		2	2	1

Note: ACR = anterior corona radiata; ALIC = anterior limb of the internal capsule; ATR = anterior thalamic radiation; BCC = body of the corpus callosum; CGC = cingulate (dorsal portion); CGH = cingulate (ventral portion); CST = corticospinal tract; EC = external capsule; GCC = genu of the corpus callosum; IC = internal capsule; IFO = inferior fronto-occipital fasciculus; ILF = inferior longitudinal fasciculus; SCR = superior corona radiata; SLF = superior longitudinal fasciculus; PTR = posterior thalamic radiation; SCC = splenium of the corpus callosum; UNC = uncinate fasciculus. ↓ Indicates that decreased FA was found in MDD as compared to HC; ↑ Indicates that increased FA was found in MDD as compared to HC. “-” Indicates that no significant difference was found between the MDD and HC groups and specific results for each tract/region were listed in the corresponding paper. “u” Indicates significant p value (uncorrected); p value was not significant after correction for multiple comparisons

Please note that 3 papers31, 32, 33 used methods or reported results that were not conducive to being summarized in the format of Table 3, and are therefore summarized separately in Table S1, available online.