. Author manuscript; available in PMC: 2024 Apr 4.

Published in final edited form as: CHEST Crit Care. 2024 Jan 9;2(1):100047. doi: 10.1016/j.chstcc.2024.100047

TABLE 4.

Association Between Admission to Hospitals Using Predominantly Opioids and Propofol for Analgesia and Sedation (vs Hospitals Using Opioids and Benzodiazepines) and Outcomes in Primary Analysis

Outcome	Adjusted β-Coefficient (95% CI)^a	P Value

Duration of MV with POD, d	−5.9 (−11.2 to −0.6)	.03
Hospital LOS with POD, d	−8.5 (−16 to −1)	.03
ICU LOS with POD, d	−7.1 (−12.4 to −1.7)	.01

	Adjusted OR (95% CI)^a

Mortality	0.4 (0.2–0.9)	.03

LOS = length of stay; MV = mechanical ventilation; POD = placement of death.

Adjusted for demographics (age, sex, race or ethnicity), BMI, preexisting comorbidities (Charlson comorbidity score, alcohol misuse disorder, substance misuse disorder), maximum Sequential Organ Failure Assessment score, initial ventilator mode, additional therapies (use of neuromuscular blockade, prone positioning, inhaled pulmonary vasodilators), pandemic timing during hospitalization, and facility factors (hospital site location, lack of hospital resources during hospitalization).