Fig. 1.

Workflow of retinoblastoma (RB) tumor cell injection into the naturally closed eye of newborn rats (P0) and the detection of luciferase signals under nanoparticle treatment. Treatment setting I: n = 12 treated and n = 10 control animals; Treatment setting II: n = 12 treated and n = 11 control animals; Treatment setting III: n = 12 treated and n = 12 control animals; LU, luminescence measurement; PT, post‐treatment; syringe: time point of nanoparticle treatment; green dropping bottle: time‐point of topical nanoparticle treatment; red arrows in the tumor histology demarcate rosette like RB tumor structures.