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Genetic map and phenotype of recombinant viruses R2 and R3. NC, noncoding region. The construction of the chimeric viruses and in vivo neurovirulence studies are from McAllister et al. (19). Mice were inoculated intracerebrally with 104 PFU of attenuated (−) or highly neurovirulent (+) virus. The cytopathic effect in neuron cultures (−, no visible cytopathic effect; +, complete cytopathic effect) was determined by observation with phase-contrast microscopy.
