TABLE A1.
Co-occurring Genomic Alterations With IDH1/2 Mutation Status
| Co-Occurring Mutation | IDH1+ iCCA | IDH1– iCCA | IDH2+ iCCA | IDH2– iCCA |
|---|---|---|---|---|
| Total cases, No. | 426 | 2,641 | 125 | 2,942 |
| TP53, % | 12 | 38 | 9 | 35 |
| CDKN2A, % | 20 | 32 | 12 | 31 |
| CDKN2B, % | 16 | 23 | 9 | 22 |
| KRAS (non-G12C), % | 6 | 21 | 2 | 20 |
| MTAP, % | 8 | 16 | 6 | 15 |
| BAP1, % | 17 | 13 | 23 | 14 |
| TERT, % | 0.2 | 8 | 2 | 7 |
| SMAD4, % | 1 | 8 | 1 | 8 |
| MYC, % | 1 | 5 | 0 | 5 |
| FGFR2 fusions, % | 1 | 10 | 1 | 9 |
| ERBB2, % | 2 | 5 | 2 | 5 |
| BRAF, % | 4 | 5 | 2 | 5 |
| PIK3CA, % | 8 | 6 | 3 | 7 |
| PTEN, % | 1 | 3 | 2 | 3 |
| KRAS G12C, % | 0.20 | 1 | 0 | 1 |
| ARID1A, % | 25 | 18 | 19 | 19 |
| PBRM1, % | 19 | 10 | 14 | 11 |
| STK11, % | 0.2 | 3 | 1 | 3 |
| MDM2, % | 1 | 5 | 2 | 4 |
| CD274 amplification, % | 0 | 0.30 | 1 | 0.20 |
Abbreviation: iCCA, intrahepatic cholangiocarcinoma.