Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The stimulator of interferon genes (STING) pathway is activated though cytosolic DNA sensors including cyclic GMP-AMP synthase (cGAS). Activation leads to the production of Type I interferons. STING agonists may synergize with various other forms of immunotherapy including CAR-T cells, CPIs, BiTEs, and radiotherapy to improve anti-tumor activity.
