Table 2.
Target genes of effective compounds of SGC.
| Mol ID | Target genes |
|---|---|
| MOL002032 | SCN5A, ADRB2, CHRM3, CHRM1, ADRA1B |
| MOL000358 | PGR, NCOA2, PTGS1, PTGS2, HSP90, PIC3KG, KCNH2, DRD1, CHRM3, CHRM1, SCN5A, GABRA2, CHRM4, PDE3A, HTR2A, GABRA5, ADRA1A, GABRA3, PON1, CHRM2, ADRA1B, ADRB2, CHRNA2, SLC6A4, OPRM1, GABRA1, CHRNA7, BCL2, BAX, CASP9, JUN, CASP3, CASP8, PRKCA, TGFB1, MAP2 |
| MOL005344 | BAX, TNF, CASP3, PTGS2, NFKBIA, IL1B, CASP1, ADCYAP1, PSMG1, MAP2K4, SLC2A4, IFNG |
| MOL001736 | PTGS1, PTGS2, HSP90, PIC3KG |
| MOL000359 | PGR, NCOA2, NR3C2 |
| MOL000492 | PTGS1, ESR1, PTGS2, HSP90, NCOA2, CALM, RXRA, CAT, HAS2 |
| MOL000073 | PTGS1, ESR1, PTGS2, HSP90 |
| MOL004576 | PTGS1, PTGS2, HSP90, PIK3CG, RXRA, AR, RELA, MAC1, ICAM1, DGAT2, MTTP, APOB |
| MOL001494 | PTGS1, PTGS2, NCOA2 |
| MOL002135 | NOS2, PTGS1, KCNH2, ESR1, SCN5A, PPARG, PTGS2, F7, RXRA, PDE3A, ADRB2, ESR2, DPP4, MAPK14, GSK3B, HSP90, CDC2, CHEK1, IGHG1, Pim-1, CCNA2, NCOA1, VEGFR2, AR |
| MOL002140 | PTGS2, RXRA |
| MOL002157 | PTGS2, NR3C2, NR3C1, NCOA2 |
| MOL000433 | CDC2, GSK3B |
ADCYAP1 = pituitary adenylate cyclase-activating polypeptide, ADRA1A = α-1A adrenergic receptor, ADRA1B = α-1B adrenergic receptor, ADRB2 = β-2 adrenergic receptor, APOB = apolipoprotein B-100, AR = aldose reductase, BAX = apoptosis regulator BAX, BCL-2 = apoptosis regulator Bcl-2, CALM = calmodulin, CASP1 = caspase-1, CASP3 = caspase-3, CASP8 = caspase-8, CASP9 = caspase-9, CAT = catalase, CCNA2 = cyclin-A2, CDC2 = cell division protein kinase 2, CHEK1 = serine/threonine-protein kinase Chk1, CHRM1 = muscarinic acetylcholine receptor M1, CHRM2 = muscarinic acetylcholine receptor M2, CHRM3 = muscarinic acetylcholine receptor M3, CHRM4 = muscarinic acetylcholine receptor M4, CHRNA2 = neuronal acetylcholine receptor subunit α-2, CHRNA7 = neuronal acetylcholine receptor protein, α-7 chain, DGAT2 = diacylglycerol O-acyltransferase 2, DPP4 = dipeptidyl peptidase IV, DRD1 = dopamine D1 receptor, ESR1 = estrogen receptor, ESR2 = estrogen receptor β, F7 = coagulation factor VII, GABRA1 = γ-aminobutyric acid receptor subunit α-1, GABRA2 = γ-aminobutyric-acid receptor α-2 subunit, GABRA3 = γ-aminobutyric-acid receptor α-3 subunit, GABRA5 = γ-aminobutyric-acid receptor α-5 subunit, GSK3B = glycogen synthase kinase-3 β, HAS2 = hyaluronan synthase 2, HSP90 = heat shock protein HSP 90, HTR2A = 5-hydroxytryptamine 2A receptor, ICAM1 = intercellular adhesion molecule 1, IFNG = interferon γ, IGHG1 = Ig γ-1 chain C region, IL1B = interleukin-1 β, JUN = transcription factor AP-1, KCNH2 = potassium voltage-gated channel subfamily H member 2, MAC1 = metal-binding activator 1, MAP2 = microtubule-associated protein 2, MAP2K4 = dual specificity mitogen-activated protein kinase 4, MAPK14 = mitogen-activated protein kinase 14, MTTP = microsomal triglyceride transfer protein large subunit, NCOA1 = nuclear receptor coactivator 1, NCOA2 = nuclear receptor coactivator 2, NFKBIA = NF-κ-B inhibitor α, NOS2 = nitric oxide synthase, inducible, NR3C1 = glucocorticoid receptor, NR3C2 = mineralocorticoid receptor, OPRM1 = µ-type opioid receptor, PDE3A = CGMP-inhibited 3’,5’-cyclic phosphodiesterase A, PGR = progesterone receptor, PIC3KG = phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform, PIK3CG = phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform, Pim-1 = proto-oncogene serine/threonine-protein kinase Pim-1, PON1 = serum paraoxonase/arylesterase 1, PPARG = peroxisome proliferator activated receptor gamma, PRKCA = protein kinase C α type, PSMG1 = proteasome assembly chaperone 1, PTGS1 = prostaglandin G/H synthase 1, PTGS2 = prostaglandin G/H synthase 2, RELA = transcription factor p65, RXRA = retinoic acid receptor RXR-α, SCN5A = sodium channel protein type 5 subunit α, SLC2A4 = solute carrier family 2, facilitated glucose transporter member 4, SLC6A4 = sodium-dependent serotonin transporter, TGFB1 = transforming growth factor β-1, TNF = tumor necrosis factor, VEGFR2 = vascular endothelial growth factor receptor 2.