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. 2023 Oct 10;147(4):1231–1246. doi: 10.1093/brain/awad349

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A single dose of ASO-84 restores neuronal excitability of Scn1a^+/− PV+ interneurons. Top: Study design. (A) Representative traces showing evoked repetitive firing of cortical layer 2/3 PV+ interneurons in slices from P21–25 wild-type (WT) (black) or Scn1a^+/− (blue) mice following one dose of ASO-84 at P2. Repetitive action potential (AP) firing was evoked using the same protocol, as described in Fig. 2. Here, wild-type and Scn1a^+/− interneurons showed similar AP firing patterns in response to current injections. (B) Input-output (I-O) curves for AP firing of wild-type versus Scn1a^+/− PV+ interneurons following ASO-84 treatment. Values are mean ± standard error of the mean (SEM) of 24 cells from 13 wild-type mice or 19 cells from 12 Scn1a^+/− mice, respectively. Study design panel generated with BioRender. ASO = antisense oligonucleotide; ICV = intracerebroventricular; PV = parvalbumin.