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. 2023 Oct 10;147(4):1231–1246. doi: 10.1093/brain/awad349

Figure 5.

Figure 5

Single-dose ASO-84 treatment restores action potential waveform and kinetics of Scn1a+/− PV+ interneurons. (A–C) Comparison of action potential (AP) duration (half-width) of untreated, PBS-treated or ASO-84-treated wild-type (WT) or Scn1a+/− P21-25 PV+ interneurons, respectively. (D–F) Comparison of maximum rise rates of APs of untreated, PBS-treated or ASO-84-treated wild-type or Scn1a+/− PV+ interneurons, respectively. (G–I) Comparison of maximum decay rates of APs of untreated, PBS-treated or ASO-84-treated wild-type or Scn1a+/− PV+ interneurons, respectively. Values are mean ± standard error of the mean (SEM) of 11–21 cells from 8–12 wild-type mice or 17–24 cells from 11–12 Scn1a+/− mice. WT = black; Scn1a+/− = blue. *Significant differences between wild-type and Scn1a+/− PV+ interneurons (P < 0.01). Results are tabulated in Supplementary Table 1. ns = not significant; PV = parvalbumin.