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. 2023 Dec 21;147(4):1553–1570. doi: 10.1093/brain/awad405

Figure 5.

Figure 5

Altered Smarcc1 expression in NPCs and disrupted neurogenesis in Smarcb1-mutant hydrocephalic mice. (A) Schematic of the human SWItch/Sucrose Non-Fermentable (SWI/SNF complex), highlighting SMARCC1 and SMARCB1, core subunits of the complex. (B) Differential expression of Smarcc1 and Smarcb1 by cell type in Smarcb1-mutant mice. Significant values are labelled numerically. (C) Representation of positively and negatively differentially expressed genes (DEGs) by log(fold-change) in hydrocephalic Smarcb1-mutant mice relative to wild-type. Neurod2 is highlighted. (D) Smarcb1-mutant positively and negatively DEGs gene ontology (GO) biological processes. Vertical green line indicates statistical significance corrected by the Benjamini-Hochberg method. (E) Smarcb1-mutant NPC-type marker GO biological processes and molecular functions. Vertical green line indicates statistical significance corrected by the Benjamini-Hochberg method. NPC = neural progenitor cell.