Figure 4.

Sex-specific modulation of cortical amyloid-β on tau phosphorylation underlies faster tau tangle accumulation in females. We proposed a novel model suggesting that males and females react differently to amyloid-β (Aβ) plaques, which consequently leads to differences in CSF phosphorylated tau (p-tau) production and causes the faster neurofibrillary tangle (NFT) accumulation observed in females. Overall, it supports the hypothesis that Aβ-dependent tau phosphorylation is an important driving force behind faster tau progression in females. Image was created with BioRender.com.