Fig 8. SARS-CoV F70S elicits a lower immune response in the lungs of infected K18-hACE2 mice.

K18-hACE2 mice were infected intranasally with 1x10⁴ pfu wild-type or DUB mutant SARS-CoV or mock-infected with DMEM. Lungs were collected at 2 and 4 dpi and immune responses were analyzed by RT-qPCR. (A) Immune responses at 2 dpi. (B) Immune responses at 4 dpi. N = 6 mice per group. Data are represented as mean ± s.e.m. Data was analyzed using Welch ANOVA with Dunnett’s T3 multiple comparisons test, comparing each group to wild-type SARS-CoV. * p<0.05, ** p<0.01.