Table 4.

Correlation of cytomorphological parameters with histological grading

		Grade		Total	p value
		non-high	high
% cohesive cells	Mean	68.5	75.7	70.1	0.194
Epithelial fragment architecture, %
Monolayer sheet	<50	50	11	61	0.173
	≥50	23	10	33
Solid aggregate	<50	49	12	61	0.398
	≥50	24	9	33
Cribriform	<50	65	20	85	0.678
	≥50	8	1	9
Papillary fragment	<50	58	20	78	0.110
	≥50	15	1	16
Inflammatory cells
Lymphocyte	Absence	29	6	35	0.351
	Present	44	15	59
Background polymorphs	Absent	25	6	31	0.626
	Present	48	15	63
Polymorphs in epithelial structures	Absent	45	11	56	0.446
	Present	28	10	38
Cellularity	Low	27	12	39	0.252
	Moderate	31	5	36
	High	15	4	19
Background composition
Calcification	Absence	70	21	91	1.000
	Presence	3	0	3
	Total	73	21	94
Comedonecrosis	Absent	68	20	88	1.000
	Present	5	1	6
	Total	73	21	94
Debris	Absent	46	10	56	0.033
	Rare	15	2	17
	Abundant	12	9	21
Hemorrhage	Absent	69	21	90	0.572
	Present	4	0	4
Histiocyte	Absent	47	14	61	0.847
	Present	26	7	33
Stromal fragment	Absent	43	14	57	0.802
	Rare	16	4	20
	Abundant	14	3	17
Apocrine change	Absent	69	18	89	1,000
	Present	4	1	5
Myoepithelial cells
Myoepithelial cells in epithelial clusters	Absent	6	0	6	0.379
	Decreased	62	19	81
	Normal	5	2	7
Background myoepithelial cells	Absent	35	8	43	0.483
	Decreased	36	13	49
	Normal	1	0	1
Nuclear features
Size (x erythrocyte size)	<2x	15	0	15	0.005
	2–2.9x	43	10	53
	≥3x	15	11	26
Nucleoli	Absent	29	2	31	0.011
	Present	31	10	41
	Prominent	13	9	22
Membrane irregularity	Smooth	20	3	23	0.043
	Mild	38	8	46
	Marked	15	10	25
Chromatin	Fine	38	6	44	0.089
	Speckled	26	9	35
	Coarse	9	6	15
Size variation	Uniform	12	1	13	0.025
	1–1.5x variation	39	7	46
	>1.5x variation	22	13	35
Mitosis	Absent	62	14	76	0.061
	Present	11	7	18
Apoptosis	Absent	65	11	76	<0.001
	Present	8	10	18
Nuclear:cytoplasmic ratio	≤0.6	40	10	50	0.561
	>0.6	33	11	44
Cytoplasm amount	Scanty/moderate	61	13	74	0.034
	Abundant	12	8	20
Vacuole	Absent	59	21	80	0.034
	Present	14	0	14