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. 2024 Mar 15;16(3):838–854. doi: 10.62347/RDXA5841

Table 5.

Fluctuations in platelet count, platelet volume, and the mean platelet volume to platelet count ratio index during the menstrual cycle, stratified into normal weight and overweight/obese participants

Group Na MESORb Amplitude Acrophaseb pZero-ampc
Platelet count
    Overall 1854 291 (288-294), <0.001* 7 (2-11), 0.006* -1.4 (-2.1--0.7), <0.001* 0.022*
        Normal weight 831 280 (275-285), <0.001* 11 (4-18), 0.003* -1.4 (-2.0--0.7), <0.001* <0.001***
        Overweight/obese 1023 301 (290-313), <0.001* 3 (-4-9), 0.377 -1.3 (-3.3-0.8), 0.238
pMESORd<0.001* pAMPe = 0.108 pACRf = 0.907
Platelet volume
    Overall 1854 8.30 (8.27-8.35), <0.001* 0.07 (0.01-0.14), 0.016* -0.8 (-1.6--0.1), 0.022* 0.056
        Normal weight 831 8.30 (8.24-8.36), <0.001* 0.12 (0.03-0.21), 0.007* -1.1 (-1.7--0.4), 0.002* 0.012*
        Overweight/obese 1023 8.31 (8.17-8.46), <0.001* 0.04 (-0.03-0.12), 0.302 -0.3 (-2.1-1.5), 0.739
pMESORd = 0.792 pAMPe = 0.184 pACRf = 0.419
MPR index
    Overall 1854 3.06 (3.01-3.10), <0.001* 0.09 (0.03-0.16), <0.001*** -1.9 (-2.0--0.6), <0.001* 0.022*
        Normal weight 831 3.19 (3.12-3.26), <0.001* 0.17 (0.07-0.27), <0.001*** -1.3 (-1.8--0.7), <0.001* <0.001***
        Overweight/obese 1023 2.94 (2.78-3.10), <0.001* 0.03 (-0.07-0.12), 0.580 -0.9 (-4.1-2.2), 0.569
pMESORd<0.001* pAMPe = 0.034* pACRf = 0.818

Abbreviations: MESOR: Midline Estimating Statistic of Rhythm; MPR: the mean platelet volume to platelet count ratio.

a

Number of participants.

b

MESOR, amplitude, and acrophase were determined using the COSINOR and COSINOR2 packages for R. Values are estimated, as well as a 95% confidence interval and p-values.

c

p-value was calculated using the cosinor. Detect function of the COSINOR2 package, which detects rhythm (also called the zero-amplitude test) and tests the overall significance of the cosinor model.

d

p-value is for the difference in MESORS and was calculated using the summary function of the COSINOR package. The result assessed the difference between the second and primary categories.

e

p-value is for the difference in amplitude and was calculated using the test_cosinor function of the COSINOR package.

f

p-value is for the difference in acrophase and was calculated using the test_cosinor function of the COSINOR package.

Significant results (two-tailed) are indicated as follows:

*

P<0.05;

***

P<0.001.