. 2024 Mar 14;68(4):e01533-23. doi: 10.1128/aac.01533-23

TABLE 1.

Optimized population pharmacokinetic model parameter estimates for metronidazole derived from plasma and estimated from plasma in two studies (9, 16) of critically ill infants with intra-abdominal infections^a

Parameter	Estimate	RSE (%)	2.5^th percentile	Bootstrap^b median	97.5^th percentile
Structural model
CL = θ_CL * WT * [PMA^Hill/(TM50^Hill+PMA^Hill)] V = θ_V * WT^θWT-V
θ_CL (L/kg/h)	0.036	4	0.033	0.036	0.039
θ_V (L/kg)	0.853	3	0.802	0.857	0.921
TM50 (weeks)	25.6	2	24.4	25.6	26.5
Hill	7	37	8.4	15.9	41.0
θ_WT-V	0.763	8	0.645	0.752	0.876
Interindividual variability (%CV)
CL	35.6	21	28.4	35.5	43.4
V	25.4	31	16.5	24.8	31.6
Residual error
Proportional error (%)	19.1	13	16.5	18.9	21.1

^{^a}

θ_CL, typical value for CL; θ_V, typical value for V; θ_WT-V, exponent of body weight on V; CL, clearance; CV, coefficient of variation; Hill, Hill coefficient in sigmoidal maturation function; PMA, postmenstrual age (weeks); TM50, maturation half-life calculated as a function of PMA (weeks); V, volume of distribution; WT, body weight.

^{^b}

1000 bootstrap runs were performed, 99.5% converged to >3 significant digits.