Fig. 5. Plasma concentrations of RAY1216 and PF-07321332 after i.v. injection dosing and gavage (p.o.) dosing in mouse and rat models.
a, The pharmacokinetics in the mouse models. b, The pharmacokinetics in the rat models. In each dosing experiment, male (circles and diamonds) and female (squares and triangles) animal groups were tested. Each group consisted of five animals, and the data of each animal are shown with group average values connected by lines. The red dashed lines represent the lower limit of quantitation (LLOQ, 1 ng ml−1) of plasma drug concentration.