Extended Data Fig. 6. NicheNet-based analysis of the effects of P. copri colonization on cell-cell signaling activities.

Each row represents different sender cell clusters. Each column represents ligands expressed by these sender cells. Cells are colored based on the log₂-fold difference in expression of ligands in the sender cell clusters between mice in ‘w/ P. copri & w/ B. infantis Bg2D9’ and ‘w/o P. copri & w/ B. infantis Bg463’ groups from the experiment described in Fig. 1. Ligands (columns) are grouped based on receiver cell clusters and the indicated functions of downstream signaling pathways in these receiver cells.