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. 2024 Apr 4;15:101. doi: 10.1007/s12672-024-00953-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Enhanced RT effects of 5FU as free RS over a range of concentrations, 0–0.25 μg/mL. b Effects on spheroid growth of FG-5FU, diluted 1:1, 2:1, 4:1. RT 0, 10 Gy. c Enhanced RT effects for MGd over a range of concentrations, 0–80 μg/mL. RT 0 and 10 Gy administered 24 h after RS. d FG- MGd diluted 1:1, 2:1, 4:1, and 8:1 with RT 10, 12 Gy Spheroid growth after 14 days. Each data point represents the average volume of 8 spheroids after 2 weeks in culture as a % of non-treated controls. Error bars, standard deviation. * Significant differences (p < 0.05) compared to controls