Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Apr 4;14:7924. doi: 10.1038/s41598-024-58579-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Cariprazine (CAR) pre- or post-treatment both resulted in increased tissue viability and decreased phospholipid oxidation in vivo. (A) shows the experimental design. For the pre-treatment experiments, postnatal day 7 (P7) mice were injected with vehicle (VEH) or 0.2 mg/kg CAR 48 h before HIBI. For the post-treatment experiments, mice were injected with vehicle or 0.2 mg/kg CAR 30 min after HIBI; (B) MDA levels assessed by TBARS are decreased in animals treated with CAR, indicating that CAR treatment decreases markers of phospholipid oxidation. (D) Tissue viability assessed by 2,3,5-Triphenyltetrazolium Chloride (TTC) reveals increased tissue viability in HIBI animals treated with CAR. (C) and (E) show correlations of MDA vs 7-DHC and tissue viability vs 7-DHC, respectively. (F) Representative TTC images for each group. *p < 0.05, **p < 0.01, ***p < 0.001 in pairwise comparison versus HIBI + VEH. Bars represent mean ± SEM of 7–10 replicates.