Table 1.
Demographics CHARIOT PRO and ADNI cohorts
| CHARIOT-PRO | ||||||
|---|---|---|---|---|---|---|
| ALL | Low performance group | Normal performance group | P value | |||
| N | 830 | 132 | 698 | |||
| Age (years) | 68.70 ± 3.51 | 69.22 ± 4.83 | 68.68 ± 3.45 | * | ||
| Female: n (%) | 475 (57.23) | 61 (46.21) | 414 (59.40) | ** | ||
| Male: n (%) | 355 (42.77) | 71 (53.79) | 283 (40.60) | |||
| APOEε4 carrier | 168 (20.24) | 34 (25.76) | 134 (19.20) | |||
| Education ≥ 13 years n (%) | 431 (51.93) | 54 (40.91) | 377 (54.01) | ** | ||
| Race | *** | |||||
| White: n (%) | 736 (88.7%) | 96 (72.7%) | 640 (91.7%) | |||
| Black or African American: n (%) | 6 (0.7%) | 5 (3.8%) | 1 (0.1%) | |||
| Asian: n (%) | 36 (4.4%) | 20 (15.2%) | 16 (2.3%) | |||
| Multiple: n (%) | 10 (1.2%) | 5 (3.8%) | 5 (0.7%) | |||
| Other: n (%) | 12 (1.4%) | 4 (3%) | 8 (1.2%) | |||
| Unknown: n (%) | 30 (3.6%) | 2 (1.5%) | 28 (4%) | |||
| RBANS | ||||||
| immediate | 103.21 ± 14.74 | 83.41 ± 12.89 | 106.96 ± 11.78 | *** | ||
| [94.00–112.00] | [75.25–90.00] | [100.00–114.00] | ||||
| (49.00–144.00) | (49.00–123.00) | (69.00–144.00) | ||||
| constructional | 97.87± 16.09 | 82.11 ± 14.19 | 100.85 ± 14.63 | *** | ||
| [87.00–109.00] | [72.00–92.00] | [92.00–112.00] | ||||
| (50.00–131.00) | (50.00–121.00) | (58.00–131.00) | ||||
| language | 104.21 ± 13.38 | 89.23 ± 12.77 | 107.05 ± 11.48 | *** | ||
| [96.00–112.00] | [83.00–98.00] | [99.00–116.00] | ||||
| (51.00–134.00) | (51.00–116.00) | (79.00–134.00) | ||||
| attention | 104.44 ± 16.05 | 87.26 ± 12.30 | 107.69 ± 14.54 | *** | ||
| [94.00–115.00] | [79.00–94.00] | [97.00–118.00] | ||||
| (49.00–146.00) | (49.00–132.00) | (68.00–146.00) | ||||
| delayed memory | 100.41 ± 11.93 | 86.67 ± 12.43 | 103.01 ± 9.89 | *** | ||
| [95.00–107.00] | [80.25–95.00] | [98.00–110.00] | ||||
| (40.00–134.00) | (40.00–113.00) | (56.00–134.00) | ||||
| TOTAL | 102.72 ± 13.83 | 80.96 ± 6.61 | 106.85 ± 10.60 | *** | ||
| [94.00–112.00] | [78.00–86.00] | [99.00–114.00] | ||||
| (55.00–143.00) | (55.00–88.00) | (89.00–143.00) | ||||
| ADNI | ||||||
| ALL | Aβ42 | t-tau | p-tau181 | sTREM2 | BACE1 activity levels | |
| N | 750 | 580 | 573 | 580 | 187 | 114 |
| Age (years) | 73.42 ± 7.03 | 73.03 ± 7.12 | 73.04 ± 7.14 | 73.03 ± 7.12 | 72.85 ± 6.82 | 74.45 ± 6.23 |
| Female: n (%) | 322 (42.93): | 250 (43.1): | 248 (43.28): | 250 (43.1): | 71 (37.97): | 41 (35.96): |
| Male: n (%) | 428 (57.07) | 330 (56.9) | 325 (56.72) | 330 (56.9) | 116 (62.03) | 73(64.04) |
| APOEε4 carrier | 306 (40.80): | 231 (39.83): | 227 (39.62): | 231 (39.83): | 75 (40.11): | 43 (37.72): |
| 444 (59.20) | 349 (60.17) | 346 (60.38) | 349 (60.17) | 112 (59.89) | 71 (62.28) | |
| Education ≥ 13 years: n (%) | 638 (85.07) | 497 (85.69) | 491 (84.66) | 497 (85.69) | 157 (83.51) | 97 (85.09) |
| Diagnosis (CN/MCI/ AD) | 255/450/45 | 188/350/42 | 187/347/39 | 188/350/42 | 47/140/0 | 55/59/0 |
| Biomarkers | 179.75 ± 54.01 | 83.15 ± 45.82 | 38.69 ± 23.02 | 4599.19 ± 2576.53 | 49.08 ± 20.04 | |
Legend: P values: * α <0.05, ** α < 0.01, *** α < 0.001; RBANS values are presented as mean ± SD [IQR] (range), other variables are presented as mean ± SD