Table 2.

Results on the out-of-fold validation for the 200 µm → 50 µm resolution models

Models	Out-of-fold evaluation
	MSE	PSNR	SSIM
Baseline 2D	0.0072 ± 0.00003	26.64 ± 0.014	0.812 ± 0.0005
Baseline 3D	0.0068 ± 0.0001	24.8 ± 0.05	0.691 ± 0.002
Structure 2D	0.0084 ± 0.0001	25.5 ± 0.05	0.776 ± 0.006
Visual 2D	0.015 ± 0.007	25 ± 1.3	0.7 ± 0.06

The best performance on each metric is bolded

Experiments with different combinations of loss functions are listed with a two-dimensional (2D) or volumetric (3D) model. The value for the standard error of mean is reported after the mean value

MSE mean-squared error, PSNR peak signal-to-noise ratio, SSIM structure similarity index