Table 5.
Analysis of 68Ga-DOTA-IBA PET/CT and 18F-NaF PET/CT in the diagnosis of bone metastases of different solid tumors.
| Tumor type | Tracers | Preliminary diagnostic results | Final diagnosis result | Detection rate (%) |
Sensitivity(%) | Specificity(%) | PPV (%) |
NPV (%) |
Accuracy (%) |
Pearson test (X2 value) |
Kappa test (Kappa value) |
McNemar test |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| + | - | ||||||||||||
| Lung cancer | 68Ga-DOTA-IBA | + | 128 | 6 | 89 | 96 | 45 | 96 | 50 | 92 | 35.104 (p<0.001) |
0.493 (p<0.001) |
P=0.100 |
| – | 5 | 5 | |||||||||||
| 18F-NaF | + | 132 | 3 | 92 | 99 | 73 | 98 | 89 | 97 | ||||
| – | 1 | 8 | |||||||||||
| Breast cancer | 68Ga-DOTA-IBA | + | 20 | 4 | 59 | 95 | 69 | 83 | 90 | 85 | 21.156 (p<0.001) |
0.767 (P<0.001) |
P=0.250 |
| – | 1 | 9 | |||||||||||
| 18F-NaF | + | 20 | 7 | 59 | 95 | 46 | 74 | 86 | 76 | ||||
| – | 1 | 6 | |||||||||||
| Prostate cancer | 68Ga-DOTA-IBA | + | 13 | 1 | 41 | 46 | 75 | 93 | 17 | 50 | 2.575 (P=0.109) |
0.149 (P=0.109) |
P<0.001 |
| – | 15 | 3 | |||||||||||
| 18F-NaF | + | 28 | 1 | 88 | 100 | 75 | 97 | 100 | 97 | ||||
| – | 0 | 3 | |||||||||||
+:Diagnosed as bone metastasis.
-:Diagnosed as non bone metastasis.