TABLE 3.

Genomic spatial structure alterations in B cells and macrophages during disease or a certain reaction.

Cell type	Disease or a certain reaction	Genomic spatial structure alterations
Macrophage	Anti-tuberculosis infection	The super-enhancer immunogenomic GBP interaction is strong, and NF-κB binds to the enhancer and promoter loops of the PD-L1 gene
	Anti-infection response	IRF1 increases the chromatin accessibility of ISG gene loci in macrophages
	Prostate cancer	The development of malignant tumors is associated with the enrichment of YY1 and H3K27ac at the IL-6 gene enhancer site
	Systemic Lupus Erythematosus	The occurrence of the disease is related to the binding of IFN-α and TNF, which leads to the opening of tolerant gene loci, resulting in the appearance of tolerant monocytes
B cell	Diffuse large B-cell lymphoma	The inactivation of the PRDM1 sequence at the TAD boundary in B cell chromatin leads to malignant proliferation of B cells
	Mantle cell lymphoma (MCL)	The chromosomal interactions in the oncogenic region of SOX11 have significantly increased
	Chronic lymphocytic leukemia	The 3D interactions and active enhancers in the EBF1 genomic region within B cells are lost in the early stage of the disease