Table 2.

Acute bed‐rest caused a decrease in leg, but not whole‐body, muscle volume, which was restored by exercise‐supplemented remobilization but not ambulation alone

A. Whole‐body muscle volume % change
	Time point	% change
Whole‐body muscle volume	Post‐bed‐rest	−0.7 ± 0.3%
	Post‐remobilization	−0.5 ± 0.3%

B. Leg muscle volume % change in the exercise‐supplemented leg (exercise + remobilization) and the non‐exercise‐supplemented leg (remobilization), measured using MRI
	Time point	Exercise + remobilization	Remobilization
Leg muscle volume % change	Post‐bed‐rest	−2.6 ± 0.5%**	−2.5 ± 0.6%**
	Post‐remobilization	−0.7 ± 0.3%	−2.3 ± 0.3%**

Note: Values are mean ± SEM. Abbreviation: MRI, magnetic resonance imaging.

^** P < 0.01 compared with pre‐bed‐rest by two‐way repeated‐measures analysis of variance (visit and leg) with Bonferroni post hoc test.