Figure 1.

Model schematic. Our hypothesis can be summarized in the model schematic. We propose that the relationships between entities, evolving dynamically through time, is sufficient to explain the decline in neurons, rise of inflammation, and increases in both amyloid plaques and tau tangles that is seen in aging, up to and including Alzheimer's disease, without requiring an external “catalytic” event such as reactive oxygen species production. This is a multi-factorial, multi-parametric viewpoint, quite different from other hypotheses in the literature. Blue arrows and asterisk identify an APOE4-dependent relation. Red arrows identify degradation relations, and red lines ending with a dot is for inhibition.