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. 2024 Mar 22;12:1360669. doi: 10.3389/fbioe.2024.1360669

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Copyright © 2024 Hall, Theodoridis, Kohli, Cegla and van Arkel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Osteopontin (OPN) expression at the (left) bone-implant interface and (right) in the bulk trabecular structure for (top; (A, B) an active osseointegrative implant specimen, (C, D) the corresponding isotypic controls for the active osseointegrative implant specimen, (E, F) a distant ultrasound treated specimen, and (bottom; (G, H) a passive implant control. Annotations indicate OPN-positive osteocytes (brown cytoplasm; ⊛), OPN-negative osteocytes (blue nuclei; ∗), osteoblasts (⁂), and osteoclasts (✽; visible in image b only).