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[177Lu]Lu-CHX-A″-DTPA-huAR9.6 still shows strong antitumor effects in recurrent tumors. (A) 72-h PET/CT imaging with [89Zr]Zr-DFO-huAR9.6 shows that OVCAR3 recurrent tumors still strongly express MUC16. Images are represented as maximum-intensity projections. (B) Individual TVs for recurrent OVCAR3 tumors. Mice were retreated with 9.25 MBq of [177Lu]Lu-CHX-A″-DTPA-huAR9.6 at day 75 of therapy. %ID = percentage injected dose; MIP = maximum-intensity projection; T = tumor.
