1 |
Galantamine |
AChEI |
62
|
2 |
Donepezil |
AChEI |
62
|
3 |
Rivastigmine |
AChEI and BChEI |
63
|
4 |
Tacrine |
AChEI and BChEI |
65
|
5 |
Metrifonate |
Irreversible AChEI and BChEI |
64
|
6 |
ABT-126 |
Selective α7 nicotinic receptor agonist |
72
|
7 |
ABT-089 |
Selective α4β2 nicotinic partial agonist |
75
|
8 |
Oxotremorine |
CNS muscarinic agonist |
77
|
9 |
Xanomeline |
CNS muscarinic agonist |
79
|
10 |
EUK1001 |
CNS muscarinic agonist |
79
|
11 |
Memantine |
NMDA antagonist |
82
|
12 |
Phencyclidine |
NMDA antagonist |
86
|
13 |
Vinpocetine |
PDE1 inhibitor |
89
|
14 |
Cilostazol |
PDE3 inhibitor |
87
|
15 |
HT-0712 |
PDE4 inhibitor |
96
|
16 |
Roflumilast |
PDE4 inhibitor |
96
|
17 |
Zatolmilast (BPN14770) |
PDE4 inhibitor |
96
|
18 |
Denbufylline |
PDE4 inhibitor |
99
|
19 |
Sildenafil |
PDE5 inhibitor |
87 and 96
|
20 |
BI-409306 |
PDE9 inhibitor |
100 and 101
|
21 |
PF-04447943 |
PDE9 inhibitor |
100 and 101
|
22 |
Propentofylline |
Broad-spectrum PDE inhibitor |
87
|
23 |
Aducanumab |
Selective anti-Aβ monoclonal antibody |
108–112
|
24 |
Lecanemab |
Selective anti-Aβ monoclonal antibody |
113–116
|
25 |
Solanezumab |
Monoclonal anti-Aβ antibody |
118 and 119
|
26 |
Bapineuzumab |
Monoclonal anti-Aβ antibody |
120 and 121
|
27 |
Ponezumab |
Monoclonal anti-Aβ antibody |
122
|
28 |
Gantenerumab |
Monoclonal anti-Aβ antibody |
119
|
29 |
AN1792 |
Purified Aβ-42 polypeptide vaccine |
125
|
30 |
ACC-001 |
N-terminal Aβ1-7 vaccine |
57
|
31 |
QS-21 |
Adjuvant combined with ACC-001 |
129 and 130
|
32 |
ABvac40 |
C-terminal end of Aβ40 vaccine |
57
|
33 |
Tramiprosate |
Inhibitor for Aβ42 oligomer formation |
133–136
|
34 |
Valitramiprosate (ALZ-801) |
Inhibitor for Aβ42 oligomer formation (prodrug) |
133
|
35 |
Sodium selenate |
PP2A activator |
140
|
36 |
Methylthioninium chloride |
PP2A activator |
142
|
37 |
Tideglusib |
GSK3β inhibitor |
145 and 146
|
38 |
Lithium chloride |
GSK3β inhibitor |
150
|
39 |
LY2811376 |
BACE-1 inhibitor |
151
|
40 |
LY2886721 |
BACE-1 inhibitor |
16 and 153
|
41 |
Umibecestat (CNP520) |
BACE-1 inhibitor |
155
|
42 |
Verubecestat (MK8931) |
BACE-1 inhibitor |
158 and 159
|
43 |
Atabecestat (JNJ-54861911) |
BACE-1 inhibitor |
161–163
|
44 |
Lanabecestat |
BACE-1 inhibitor |
167
|
45 |
Elenbecestat (E2609) |
BACE-1 inhibitor |
169
|
46 |
NB-360 |
Dual BACE-1 and BACE-2 inhibitor |
171
|
47 |
RG712 |
Dual BACE-1 and BACE-2 inhibitor |
174
|
48 |
Semagacestat (LY450139) |
γ-Secretase inhibitor |
178
|
49 |
MK-0752 |
γ-Secretase inhibitor |
154
|
50 |
Avagacestat (BMS-708163) |
Selective γ-secretase inhibitor |
182
|
51 |
Begacestat (GSI-953) |
Selective γ-secretase inhibitor |
186
|
52 |
PF-3084014 |
Notch sparing γ-secretase inhibitor |
189 and 190
|
53 |
Ibuprofen |
First generation GSM |
194 and 195
|
54 |
Indomethacin |
First generation GSM |
194 and 195
|
55 |
Sulindac |
First generation GSM |
194 and 195
|
56 |
Tarenflurbil |
Second generation GSM |
197
|
57 |
JNJ-40418677 |
Second generation GSM |
202
|
58 |
EVP-0015962 |
Second generation GSM |
203
|
59 |
Itanapraced (CHF5074) |
Second generation GSM |
205
|
60 |
BIIB042 |
Second generation GSM |
203 and 208
|
61 |
E2012 |
Second generation GSM |
154 and 210
|
62 |
E2212 |
Second generation GSM |
211
|
63 |
BMS-869780 |
Second generation GSM |
214
|
64 |
BMS-932481 |
Second generation GSM |
154
|
65 |
PF-06648671 |
Second generation GSM |
215
|
66 |
SPI-014 |
Second generation GSM |
217
|
67 |
SPI-1865 |
Second generation GSM |
217
|
68 |
Dihydroergocristine |
Second generation GSM |
219
|
69 |
Acitretin |
α-Secretase activator |
223
|
70 |
Etazolate (EHT-0202) |
GABAA modulator & α-secretase activator |
225
|
71 |
PF-05212377 (SAM-760) |
Selective 5-HT6R antagonist |
57 and 231
|
72 |
Iadalopirdine |
Selective 5-HT6R antagonist |
233
|
73 |
Varoglutamstat (PQ-912) |
QC inhibitor |
235
|
74 |
Etanercept |
Competitive TNF-α inhibitor |
243
|
75 |
Thalidomide |
Immunomodulator & TNF-α inhibitor |
244
|
76 |
Muscimol |
GABAA agonist |
250
|
77 |
Propofol |
GABAA agonist |
250
|
78 |
SGS742 (CGP36742) |
GABAB antagonist |
251
|
79 |
CGP55845 |
GABAB antagonist |
254
|
80 |
Vitamin E |
Antioxidant |
257 and 258
|
81 |
Caffeine |
Antioxidant |
261
|
82 |
Silibinin |
Antioxidant |
262
|
83 |
Curcumin |
Antioxidant |
263
|
84 |
Quercetin |
Antioxidant |
264
|
85 |
Luteolin |
Antioxidant |
265
|
86 |
α-Lipoic acid |
Mitochondrial-targeted antioxidant |
261 and 266
|
87 |
Coenzyme Q10 |
Mitochondrial-targeted antioxidant |
261
|
88 |
Melatonin |
Antioxidant |
267–271
|
89 |
Selegiline |
Antioxidant |
258 and 261
|