Table 1. MIC₅₀ and MIC₉₀ of Corramycin and Reference Antibiotics among 57 Multidrug-Resistant Escherichia coli Clinical Isolates^a.

		MIC [μg mL–1]
antibiotic	EUCAST CBP25 [μg mL–1]	MIC range (n = 57)	MIC50	MIC90
corramycin	n/a	2 to >64	8	16
amikacin	8	4 to 64	16	32
gentamicinb	2	2 to >64	>64	>64
kanamycinc	n/a	4 to >64	>64	>64
neomycind	n/a	2 to >64	4	>64
tobramycin	2	2 to >64	32	>64
imipenem	2	0.25 to 2	0.5	1
colistin	2	0.25 to 0.5	0.5	0.5
ciprofloxacin	0.25e	0.016 to >8	>8	>8
levofloxacin	0.5	0.03 to >16	16	>16
tetracycline	n/a	2 to >64	>64	>64
trimethoprim	4f	0.5 to >64	>64	>64

^aMinimum inhibitory concentrations (MICs) were determined in cation-adjusted Mueller-Hinton broth (MHB2) using the broth microdilution method according to the EUCAST guidelines. Values represent two independent repeats. CBP: clinical breakpoint; EUCAST: European Committee on Antimicrobial Susceptibility Testing; n/a: not available.

^bCombination of gentamicin C₁, C_1a, and C₂.

^cMain component kanamycin A.

^dMain component neomycin B.

^eIndications other than meningitis.

^fUncomplicated urinary tract infections (UTI).