Figure 1.

(A) Selected pharmaceutical compounds containing the α-branched alkylamine motif. (B) First-generation silane/visible-light-mediated carbonyl alkylative amination (CAA) and its limitations. (C) Design plan second-generation CAA: zinc-mediated carbonyl alkylative amination via capture of unactivated alkyl radical or alkyl zinc species. (D) Zinc-mediated carbonyl alkylative amination: a robust and general method for the efficient synthesis of complex alkylamines enabling an extensive reaction scope.