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. 2024 Apr 5;24:420. doi: 10.1186/s12885-024-12107-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Low VMRI is associated with better immunotherapy response. Differences in immunostimulatory genes (A) and immunosuppressive genes (B) between high and low VMRI groups. (C) IPS scores of anti-PD1(-)CTLA4(-), anti-PD1(+)CTLA4(-), anti-PD1(-)CTLA4(+), and anti-PD1(+)CTLA4(+) blockers in the high and low VMRI groups. (D) Differences in TIDE, MSI, Exclusion, and Dysfunction between high and low VMRI groups. (E) Differences in VMRI scores between immunotherapy-responsive and non-responsive groups in the Imvigor210 cohort. (F) Survival curves for high/low VMRI groups in the Imvigor210 cohort. (G-H) VMRI score for immunotherapy efficacy in pan-cancer. (I) Association of VMRI with genes related to immunotherapy efficacy. Note * p < 0.05, **p < 0.01, ***p < 0.001