Table 1.
Study cohort data and neuropathological scoring. Cases were selected by pathology and grouped into four cohorts: Control; MIX; AD; LBD. Neuropathological scores were evaluated by a board-certified neuropathologist
| Case # | Study group | Pathological diagnosis | Thal | Braak | Cerad | LB Score (McKeith) | APOE | Gender | Age | PMI | Exp |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Control | PART, definite, Braak II | 0 | II | None | None | 3/3 | m | 85 | NA | 1 |
| 2 | Control | Atherosclerosis (moderate) | 0 | 0 | None | None | 3/3 | m | 71 | NA | 1 |
| 3 | Control | Atherosclerosis (moderate) | 0 | 0 | None | None | 3/3 | m | 88 | 5 | 1 |
| 4 | Control | PART, definite, Braak I | 0 | I | None | None | 3/3 | m | 87 | NA | 1 |
| 5 | Control | PART, definite, Braak I | 0 | I | None | None | 3/3 | m | 77 | NA | 1 |
| 6 | Control | Acute microinfarcts | 0 | 0 | None | None | 3/3 | m | 72 | 4 | 1 |
| 7 | Control | PART, definite, Braak I | 0 | I | None | None | 2/3 | f | 73 | NA | 1 |
| 8 | Control | PART, definite, Braak II | 0 | II | None | None | N/A | f | 82 | NA | 1 |
| 9 | Control | PART, definite, Braak II | 0 | II | None | None | 3/3 | f | 90 | NA | 1 |
| 10 | Control | PART, definite, Braak I | 0 | I | None | None | 3/3 | f | 78 | 5 | 1 |
| 11 | Control | PART, definite, Braak I | 0 | I | None | None | 2/3 | m | 74 | 5 | 1 |
| 12 | Control | PART, definite, Braak II | 0 | II | None | None | 3/3 | m | 77 | 6 | 1 |
| 13 | Control | PART, definite, Braak I | 0 | I | None | None | 2/3 | m | 51 | NA | 1 |
| 14 | Control | PART, definite, Braak I | 0 | I | None | None | 2/3 | m | 52 | NA | 1 |
| 15 | Control | Atherosclerosis (moderate) | 1 | I | None | None | 3/3 | m | 84 | NA | 1,2 |
| 16 | Control | PART, Braak I | 0 | I | None | None | 3/3 | f | 76 | 10 | 1,2 |
| 17 | Control | PART, Braak I | 0 | I | None | None | 3/3 | m | 71 | 6 | 1,2,3 |
| 18 | Control | AD low | 1 | II | None | None | 3/3 | m | 90 | 14 | 1,2 |
| 19 | Control | AD low | 1 | II | None | None | 3/3 | m | 88 | 4 | 1,2 |
| 20 | Control | PART, definite, Braak II | 0 | II | None | None | 3/3 | f | 72 | 4 | 1,2,3 |
| 21 | Control | CVD | 1 | II | None | None | 3/3 | f | 90 | 56 | 1,3 |
| 22 | Control | PART, definite, Braak II | 0 | II | None | None | 3/3 | m | 77 | 12 | 1,2 |
| 23 | Control | Control | 0 | 0 | None | None | 3/4 | f | 55 | 12 | 1,2,3 |
| 24 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 4/4 | f | 78 | 13 | 1 |
| 25 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 3/4 | m | 78 | 22 | 1 |
| 26 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 4/4 | m | 90+ | 14.25 | 1 |
| 27 | MIX | AD high | 4 | V | Frequent | Diffuse neocortical | 3/4 | f | 76 | 20 | 1,3 |
| 28 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 3/3 | m | 83 | 69 | 1 |
| 29 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 3/3 | m | 62 | 5 | 1,3 |
| 30 | MIX | AD high | 5 | VI | Frequent | Limbic-transitional | 4/4 | f | 76 | 3 | 1 |
| 31 | MIX | AD high | 5 | VI | Frequent | Limbic-transitional | 3/3 | f | 81 | 7 | 1 |
| 32 | MIX | AD high | 5 | VI | Frequent | Limbic-Transitional | 3/4 | m | 64 | 6 | 1 |
| 33 | MIX | AD high | 5 | V | Frequent | Limbic-transitional | 3/3 | f | 78 | 12 | 1 |
| 34 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 3/3 | f | 63 | 12 | 1 |
| 35 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 2/3 | f | 90+ | 9 | 1 |
| 36 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 4/4 | f | 90+ | 18 | 1 |
| 37 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 4/4 | f | 75 | NA | 1,3 |
| 38 | MIX | AD high | 5 | V | Frequent | Limbic-Transitional | 4/4 | f | 85 | NA | 1 |
| 39 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 3/4 | m | 74 | 7 | 1 |
| 40 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 3/3 | m | 87 | 9 | 1,2,3 |
| 41 | MIX | AD high | 4 | V | Frequent | Diffuse neocortical | 3/4 | m | 77 | 17 | 1,2,3 |
| 42 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 3/4 | f | 83 | 6 | 1,2,3 |
| 43 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 3/4 | m | 80 | 21 | 1,2,3 |
| 44 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 2/4 | f | 74 | 8 | 1,2 |
| 45 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 3/4 | f | 68 | 6 | 1,2,3 |
| 46 | AD | AD high | 5 | VI | Frequent | None | 3/4 | m | 81 | 4 | 1 |
| 47 | AD | AD high | 5 | VI | Frequent | None | 3/4 | m | 63 | 2 | 1 |
| 48 | AD | AD high | 5 | VI | Frequent | None | 3/3 | m | 66 | 5 | 1,3 |
| 49 | AD | AD high | 4 | V | Frequent | None | 3/4 | m | 77 | 5 | 1 |
| 50 | AD | AD high | 5 | V | Frequent | None | 2/4 | f | 90+ | 10 | 1 |
| 51 | AD | AD high | 5 | V | Frequent | None | 3/3 | m | 90+ | 5 | 1 |
| 52 | AD | AD high | 5 | VI | Frequent | None | 3/3 | m | 83 | 7 | 1 |
| 53 | AD | AD high | 5 | VI | Frequent | None | 3/4 | m | 59 | 7 | 1,3 |
| 54 | AD | AD high | 5 | V | Frequent | None | 3/3 | f | 64 | 12 | 1 |
| 55 | AD | AD high | 5 | VI | Frequent | None | 4/4 | m | 74 | 36 | 1 |
| 56 | AD | AD high | 5 | V | Frequent | None | 3/4 | f | 86 | 14 | 1 |
| 57 | AD | AD high | 5 | VI | Frequent | None | 3/3 | m | 60 | 20 | 1 |
| 58 | AD | AD high | 5 | VI | Frequent | None | 4/4 | m | 70 | 8 | 1,3 |
| 59 | AD | AD high | 5 | V | Frequent | None | 2/3 | m | 74 | 2 | 1 |
| 60 | AD | AD high | 4 | VI | Frequent | None | 4/4 | m | 75 | NA | 1 |
| 61 | AD | AD high | 5 | VI | Frequent | None | N/A | f | 75 | NA | 1 |
| 62 | AD | AD high | 5 | VI | Frequent | None | 3/3 | f | 86 | 6 | 1 |
| 63 | AD | AD high | 5 | VI | Frequent | None | 3/3 | f | 84 | NA | 1,3 |
| 64 | AD | AD high | 5 | V | Frequent | None | N/A | f | 82 | NA | 1 |
| 65 | AD | AD high | 5 | V | Frequent | None | 3/3 | f | 90 | NA | 1 |
| 66 | AD | AD high | 5 | V | Frequent | None | 3/3 | m | 87 | NA | 1 |
| 67 | AD | AD high | 5 | V | Frequent | None | 3/3 | m | 73 | NA | 1 |
| 68 | AD | AD high | 4 | V | Frequent | None | 3/4 | m | 84 | 16 | 1,2 |
| 69 | AD | AD high | 4 | V | Frequent | None | 3/4 | f | 85 | 18 | 1 |
| 70 | AD | AD high | 5 | V | Frequent | None | 3/4 | f | 72 | 12 | 1,2 |
| 71 | AD | AD high | 5 | V | Frequent | None | 3/3 | f | 78 | 5 | 1,2 |
| 72 | AD | AD high | 4 | V | Frequent | None | 3/3 | f | 78 | 20 | 1 |
| 73 | AD | AD high | 5 | V | Frequent | None | 3/4 | m | 78 | 20 | 1,2 |
| 74 | AD | AD high | 5 | VI | Frequent | None | 3/3 | m | 83 | 18 | 1,2 |
| 75 | LBD | LBD | 3 | II | None | Limbic-transitional | 3/3 | m | 83 | 18 | 1 |
| 76 | LBD | LBD | 3 | II | Sparse | Diffuse neocortical | 3/4 | m | 68 | 8 | 1,3 |
| 77 | LBD | LBD | 3 | I | None | Diffuse neocortical | 2/3 | m | 69 | 3 | 1 |
| 78 | LBD | LBD | 2 | I | None | Brainstem predominant | 3/3 | m | 77 | NA | 1 |
| 79 | LBD | LBD | 0 | I | None | Diffuse neocortical | 2/3 | m | 80 | 3 | 1,3 |
| 80 | LBD | LBD | 2 | II | None | Limbic-transitional | 3/3 | f | 86 | 11 | 1,3 |
| 81 | LBD | LBD | 3 | I | None | Brainstem predominant | 3/3 | m | 57 | 17 | 1,3 |
| 82 | LBD | LBD | 2 | I | None | Brainstem predominant | 3/3 | m | 84 | 13 | 1,3 |
| 83 | LBD | LBD | 3 | II | None | Diffuse neocortical | 3/3 | f | 67 | 8 | 1 |
| 84 | LBD | LBD | 3 | II | Sparse | Brainstem predominant | 2/3 | m | 90+ | 9 | 1,3 |
| 85 | LBD | LBD | 1 | II | None | Limbic-transitional | 3/4 | m | 75 | 12 | 1 |
| 86 | LBD | LBD | 3 | II | None | Diffuse neocortical | 3/4 | m | 80 | 7 | 1 |
| 87 | LBD | LBD | 3 | II | None | Diffuse neocortical | 3/3 | m | 83 | NA | 1 |
| 88 | LBD | LBD | 3 | II | None | Diffuse neocortical | 3/3 | m | 76 | 11 | 1,2 |
| 89 | LBD | LBD | 3 | II | Moderate | Diffuse neocortical | 3/3 | m | 80 | 4 | 1,2,3 |
| 90 | LBD | LBD | 3 | II | Sparse | Diffuse neocortical | 3/3 | m | 79 | < 15 | 1,2,3 |
| 91 | LBD | LBD | 0 | II | None | Diffuse neocortical | 3/3 | m | 85 | 12 | 1,2,3 |
| 92 | LBD | LBD | 1 | II | None | Diffuse Neocortical | 3/3 | m | 62 | 10 | 1,2,3 |
| 93 | LBD | LBD | 1 | II | Sparse | Diffuse neocortical | 3/3 | m | 81 | 3 | 1,2 |
Thal Thal phases; Braak Braak stages; CERAD Neuritic plaque score; LB Score (McKeith) Lewy body scoring after Ian G. McKeith; APOE APOE genotype; CVD Cerebral vascular dementia. Exp:1– IHC, 2 – nCounter, 3 – GeoMx DSP