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. 2024 Apr 5;24:119. doi: 10.1186/s12866-024-03278-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The microbiota functional characterization in obesity. Differential enrichment analysis of the KOs (A) and KEGG pathways (B) between the obesity and control groups. KOs or KEGG pathways with LDA > 2.0 and p < 0.05 are shown. Blue and red color represent obesity- and control- enriched KOs or pathways, respectively. (C) Taxon-level contribution profiles of the functional shift in the obesity. The x-axis depicts the ranking and statistical scores, while the y-axis represents the associated pathways. Taxa attenuating each functional shift are presented on the left side of the vertical line, whereas those driving each functional shift are depicted on the right side of the vertical line. For each KEGG pathway, the top bars represent contributions from obesity-associated taxa and the lower bars represents contributions from obesity-depleted taxa. Red diamonds represent taxa-based functional shift scores