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[Preprint]. 2024 Mar 26:2024.03.22.24304756. [Version 1] doi: 10.1101/2024.03.22.24304756

Figure 6. Severus identifies clinically relevant rearrangements in pediatric leukemia samples.

Figure 6.

(A) Number of germline (left) and somatic (right) SV calls in pediatric leukemia samples. (B) Reciprocal translocation event between chr 2 and chr 5 leading to an NPM1::ALK fusion in CM3. (C) Cryptic multi-breakpoint reciprocal translocation between chr10 and chr11 in CM2 leads to a KMT2A::MLLT10 fusion. (D) Severus graph and IGV screenshots of translocation breakpoints in chr10 and 11. Reads are colored with the haplotype in IGV screenshots.