Figure 4. Genetic analysis of Lingo factors.

4.A. Brain related polygenic score (PGS) correlations with Lingo factor 2 scores for European SPARK participants with available genetic data (N = 811). Due to the multiple testing burden we used FDR p-value correction. Plotted are the Pearson’s R and 95% confidence interval estimates for correlations between PGS and Lingo factor 2 scores. 4.B. Parental score on Lingo factor 2 was associated with their child’s language impairment. 4.C. Parental score on Lingo factor 2 are an independent predictor of their child’s language impairment after accounting for their child’s cognitive impairment, age, and sex. Odds’ ratios and 95% confidence interval computed from a multivariate logisitc regression model predicting the child’s language impairment are shown. ”***” indicates p-value < 0.001, ”**” indicates p-value < 0.01, and ”*” indicates p-value < 0.05.