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[Preprint]. 2024 Jun 29:2024.03.26.24304802. Originally published 2024 Mar 28. [Version 3] doi: 10.1101/2024.03.26.24304802

Figure 4: A failure to resect tissue proximal to electrode contacts generating autonomous, high-rate fast ripples (FR) sites correlate with a non-seizure free outcome.

Figure 4:

(A) K-means clustered scatter plot of the logarithm of the FR rate (FR on oscillations > 350 Hz, and all FR on spikes) on the x-axis, and the corresponding nodal local efficiency on the y-axis. In cluster #1 (blue) the electrode contacts (i.e., nodes) higher rates of FR had a lower nodal local efficiency. Low local efficiency corresponds with lower mutual information and more autonomy in FR generation (i.e., a loss of synchrony). (B) Box and scatter plot of the number of Cluster #1 nodes (unresected; points in blue in panel A) in each of the 18 patients dichotomized as seizure free and non-seizure free. Patients with non-seizure free outcomes had a significantly larger number of unresected autonomous, high-rate FR sites (Kruskal-Wallis Chi-sq 5.62, p=0.02, n=18).