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[Preprint]. 2024 Mar 25:rs.3.rs-3991430. [Version 1] doi: 10.21203/rs.3.rs-3991430/v1

Figure 5. Progression to simplicity in binding moiety of resistance-evading antibiotics targeting Lipid II.

Figure 5

Vancomycin binds to the pentapeptide that can be modified by a biochemical bypass replacing the terminal D-alanine with lactate (red); teixobactinbinds to sugar-PiPi, and clovibactinbinds to PiPi. Abbreviations: GlcNAcis N-Acetylglucosamine; MurNAcis N-Acetylmuramic acid.