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[Preprint]. 2024 Mar 28:rs.3.rs-4054151. [Version 1] doi: 10.21203/rs.3.rs-4054151/v1

Table 2.

Multivariable Stepwise Binary Logistic and Linear Model for predictors of Weight Change Among South Asian Americans in the MASALA Study

Variable Logistic regression for Weight Change ≥ 5% Linear regression for weight increase (per kg)
aOR (95% CI) p-value Beta coefficient (95% CI) p-value
Age 0.98 (0.96–1.01) 0.100 0.05 (−0.08–−0.02) 0.004
Female Sex 1.51 (1.02–2.24) 0.040 0.13 (−0.42–0.67) 0.650
BMI at exam 1 0.96 (0.91–1.01) 0.157 0.02 (−0.04–0.09) 0.489
Years lived in the US 0.98 (0.96–0.99) 0.041 -0.01 (−0.04–0.01) 0.381
Glucose tolerance status: normal

Prediabetes
Reference

0.85 (0.54–1.33)
0.475 Reference

−0.23 (−0.870.41)
0.483
Diabetes 0.38 (0.21–0.70) 0.002 −1.60 (−2.39–−0.82) <0.001
Hypertension 0.70 (0.45–1.06) 0.087 −0.19 (−0.75–0.37) 0.513
Adiponectin (per SD) 1.39 (1.13–1.71) 0.002 0.34 (0.05–0.62) 0.019
Interaction testing
BMI** category x sex

Overweight males
0.42 (0.22–0.82) 0.011 −0.73 (−1.61–0.15) 0.104
Overweight females 0.51 (0.24–1.07) 0.076 −0.60 (−1.64–0.45) 0.262
Males with obesity 0.19 (0.06–0.57) 0.003 –1.87 (−3.26–−0.47) 0.009
Females with obesity 0.38 (0.13–1.16) 0.089 −1.08 (−2.58–0.43) 0.161
Normal BMI Reference Reference
BMI **x glucose tolerance Overweight, no diabetes 0.56 (0.22–1.41) 0.216 0.07 (−1.22–1.37) 0.911
Overweight, prediabetes 0.36 (0.18–0.70) 0.003 −1.04 (−1.95–0.14) 0.024
Overweight, diabetes 0.66 (0.21–2.05) 0.475 −0.54 (−1.92–0.84) 0.443
Obesity, no diabetes 0.17 (0.04–0.65) 0.010 −2.39 (−4.18–−0.59) 0.009
Obesity, prediabetes 0.35 (0.12–1.01) 0.052 −1.05 (−2.44–0.35) 0.141
Obesity, diabetes 0.10 (0.02–0.54) 0.007 −2.18 (−3.99–−0.38) 0.018
Normal BMI and no diabetes Reference Reference
BMI** x adiponectin (per SD) Overweight 0.74 (0.58–0.93) 0.010 −0.21 (−0.53–0.10) 0.176
Obesity 0.65 (0.43–0.97) 0.034 −0.35 (−0.89–0.18) 0.199
Normal BMI Reference Reference Reference Reference
Adiponectin x sex
Females 0.80 (0.54–1.18) 0.262 0.07 (−0.46–0.60) 0.794
Males Reference Reference
BMI **x waist change groups (stable versus gain)
Normal BMI and waist gain 2.99 (1.41–6.39) 0.004 1.31 (0.35–2.27) 0.007
Overweight and waist stable 0.44 (0.23–0.84) 0.013 −0.91 (−1.71–−0.11) 0.025
Overweight and waist gain 1.57 (0.76–3.25) 0.224 4.59 (0.48–2.33) 0.003
Obesity and waist stable 0.20 (0.07–0.61) 0.005 –1.06 (−3.10–−0.54) 0.005
Obesity and waist gain 1.06 (0.34–3.27) 0.918 4.94 (−0.89–1.92) 0.469
Normal BMI and waist stable Reference Reference

aOR: Adjusted odds ratios from multivariable logistic regression models adjusting for age, sex, BMI, number of years lived in the US at exam 1

BMI**: by Asian BMI category