Figure 3.

Vaccine effectiveness of mRNA-1273 bivalent vaccine vs ≥ 2 monovalent mRNA vaccines against infection and severe outcomes with SARS-CoV-2 variants, overall and by subpopulation.

BMI = body mass index, ED/UC = emergency department/urgent care, rVE = relative vaccine effectiveness.

^aApplied conditional logistic models conditioned on matched pairs for overall and age-stratified populations. Models for immunocompromised and history of SARS-CoV-2 infection are unconditional logistic models, adjusted for age, sex, race/ethnicity, and month of specimen collection, in addition to the covariates listed below.

^bAdjusted for days since last monovalent dose, time since history of SARS-CoV-2 infection, history of SARS-CoV-2 molecular test, number of outpatient and virtual visits, number of emergency department visits, BMI, Charlson comorbidity score, frailty index, pregnancy, medical center area, and number of monovalent doses prior to index date.

^cMedical center area dropped due to lack of model convergence.

^dBMI dropped due to lack of model convergence.

^ePregnancy dropped due to lack of model convergence or not being applicable (for subgroup ≥65 years of age).

^fFrailty index dropped due to lack of model convergence.

^gCharlson comorbidity score dropped due to lack of model convergence.

^hNumber of monovalent doses prior to index date dropped due to lack of model convergence.