Cytotoxic IC50 values of the tested compounds against MCF-7, HepG2, and MCF-10A cell lines using the MTT assaya.
| Compounds no. | IC50 ± SD [μM] | ||
|---|---|---|---|
| MCF-7 | HepG2 | MCF-10A | |
| 2 | 16.9 ± 0.45 | 15.6 ± 0.69 | NT |
| 3 | ≥50 | 1.17 ± 0.24 | NT |
| 4 | 0.57 ± 0.14 | 1.13 ± 0.19 | 47.6 ± 3.1 |
| 5 | 11.2 ± 0.54 | 13.4 ± 0.27 | NT |
| 6 | 1.29 ± 0.23 | 2.1 ± 0.24 | 43.5 ± 2.9 |
| 7 | 29.6 ± 0.8 | ≥50 | NT |
| 8 | 9.6 ± 0.24 | 8.1 ± 0.24 | NT |
| 9 | 3.15 ± 0.14 | 4.6 ± 0.34 | NT |
| 10 | 1.4 ± 0.24 | 1.79 ± 0.14 | ≥50 |
| 11 | 1.31 ± 0.28 | 0.99 ± 0.17 | ≥50 |
| Staurosporine | 6.76 ± 0.51 | 5.07 ± 0.36 | NT |
a
Values are expressed as mean ± SD of three independent triplets (n = 3). NT: non-tested. Staurosporine is a potent anticancer agent as a potent PIM-1 kinase inhibitor.31