Table 4. Criteria for the diagnosis of serotonin syndrome.

^#The Boyer criteria are more specific than the Sternbach criteria [10]

Criteria for diagnosis of serotonin syndrome
Hunter Criteria [9]	Sternbach  Criteria [10]	Boyer Criteria# [10]
Presence of a serotonergic agent plus one of the following criteria:	Presence of at least three of the following criteria, in the absence of the use of neuroleptics or another etiology:	Presence of a serotoninergic agent administered in the previous five weeks and any of the following criteria (already described in Hunter's criteria):
Spontaneous clonic spasm	Altered mental status	Spontaneous clonic spasm
Inducible clonic spasm + agitation or diaphoresis	Agitation	Inducible clonic spasm + agitation or diaphoresis
Ocular clonic spasm + agitation or diaphoresis	Myoclonus	Ocular clonic spasm + agitation or diaphoresis
Tremor + hyperreflexia	Hyperreflexia	Tremor + hyperreflexia
Hypertonia + temperature > 38ºC + Ocular or inducible clonic spasm	Diaphoresis	Muscle rigidity + temperature > 38ºC + inducible or ocular clonic spasm
	Shivering
	Tremor
	Diarrhea
	Discoordination
	Fever