Table 1.
Clinical and Histopathological Characteristics of Children and Young Adults With Primary Uveal Melanoma
| Characteristic | |
|---|---|
| Sex | |
| Male | 37 (45%) |
| Female | 46 (55%) |
| Mean age at diagnosis (y) | 17 (5.0–24.8) |
| Treatment* | |
| Surgery | 56 (67%) |
| Enucleation | 50 (60%) |
| Local resection | 6 (7%) |
| Endoresection† | 2 (2%) |
| Radiotherapy | 41 (49%) |
| Ruthenium | 12 (14%) |
| Iodine | 7 (8%) |
| Brachytherapy | 3 (4%) |
| Proton beam | 11 (13%) |
| External beam | 3 (4%) |
| Cyber knife | 3 (4%) |
| Gamma knife | 2 (2%) |
| Metastatic disease | |
| Yes | 12 (15%) |
| No | 68 (85%) |
| Mean metastasis free survival (y) | 9.0 (0.01–43.7) |
| Cell type | |
| Spindle cell | 17 (50%) |
| Epithelioid | 6 (18%) |
| Mixed | 11 (32%) |
| Ciliary body involvement | |
| Yes | 34 (41%) |
| No | 49 (59%) |
| Extraocular extension | |
| Yes | 7 (9%) |
| No | 75 (91%) |
| Mean largest basal tumor diameter (mm) | 12.7 (4.0–20.4) |
| Mean maximum tumor thickness (mm) | 8.1 (1.0–20.0) |
*
Combined treatment in some patients.
†
Enucleation as secondary treatment. The total amount of patients included in this study is not represented in all categories because of missing data.