FIG. 3.

Effects of immunomodulation on the level of dystrophin expression after primary AdV-Dys administration to adult mdx mouse muscles. The total number of dystrophin-expressing myofibers on an entire cross-section of the anterior tibialis muscle was determined 30 days after AdV-Dys administration. Values are expressed as means ± standard errors (n = 3 to 4 animals/group). As can be seen, the combination of FK506 plus CTLA4Ig led to a major increase in transduction efficiency over that attained when either CTLA4Ig or FK506 was used in isolation.